Thiazide diuretics

Bendroflumethiazide (bendrofluazide)
Metolazone

Indications

• Hypertension
• Chronic heart failure

Mechanism of action

• Inhibit sodium reabsorption in proximal tubule

Side-effects

• Postural hypotension
• Hypokalaemia
• Hyponatraemia
• Erectile dysfunction
• Gout
• Rash
• Nausea

Cautions/contraindications

• Severe renal impairment
• Hypokalaemia
• Hyponatraemia
• Addison's disease