- Rheumatoid factor is always present
- Lung features may precede arthropthy
Systemic lupid erythematosus
- Pleurisy/ pleural effusion
Systemic sclerosis
- Pulmonary fibrosis/ honeycomb lung
Wegener's granulomatosis
- Granulomatous vasculitis of small arteries
- Rhinorrhoea
- Nasal ulceration
- Nodular masses (+/- cavitation)
- Migratory pulmonary infiltrates
- Associated with antineutrophil cytoplasmic antibodies (c-ANCA)
- Treated with cyclophosphamide
Churg-Strauss syndrome
- Systemic vasculitis
- Asthma
- Rhinitis
- Eosinophilia
- Associated with ANCA (p-ANCA)
- Treated with steroids
Goodpasture's syndrome
- Disease associated with anti-glomerular basement membrane (GBM) antibodies which cross-react with the glomerulus and the lung
- Cough
- Haemoptysis (Can be massive)
- Intrapulmonary haemorrhage
- Glomerulonephritis
- Treated with steroids
Pulmonary fibrosis and honeycomb lung
- Localised
- Systemic sclerosis
- Sarcoidosis
- Tuberculosis
- Asbestosis
- Berylliosis
- Diffuse
- Cryptogenic fibrosing alveolitis
- Rheumatoid lung
- Langerhans' cell histiocytosis
- Tuberous sclerosis
- Neurofibromatosis
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