Spironolactone
Indications
In addition to postassium-wasting diuretics
Chronic heart failure (spironolactone)
- Ascites due to liver disease
Mechanism of action
- Spironolactone inhibits aldosterone
- Amiloride blocks renal sodium uptake
Side effects
- GI disturbance
- Hyperkalaemia
- Hyponatraemia
- Erectile dysfunction
- Gynaecomastia (spironolactone)
- Rash
Cautions/contraindications
- Severe renal impairment
- Hyperkalaemia
- Hyponatraemia
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