Unwanted effects of drugs used in affective disorders

Tricyclic antidepressants

• Anticholinergic effects
• Dry mouth
• Constipation
• Tremor
• Blurry vision
• Urinary retention
• Postural hypotension
• Cardiac effects
• ECG changes
• Arrhythmias

• Lowered seizure threshold
• Weight gain
• Sedation
• Mania

Lithium

• GI symptoms
• Hypothyroidism
• Fine tremor
• Weight gain (increased appetite)
• Polyuria/polydipsia
• Toxic symptoms
• Drowsiness
• Blurred vision
• Tremor
• Ataxia
• Dysarthria
• Convulsions
• Coma and death